🌿 Ingredient Spotlight · 5 min read · Last reviewed: September 2026
The innovative plant-produced peptide technology supporting skin renewal, firmness and vitality.
Some skincare ingredients come directly from plants. Others are created entirely through modern science.
Reneseed™ brings these two worlds together.
This advanced biomimetic peptide technology is produced using plants as biofactories and is designed to support the processes associated with skin renewal, firmness and a healthier-looking complexion.
It is one of the two specialised peptide technologies at the heart of our Re-Gen Peptide Power Serum.
What Is Reneseed™?
Reneseed™ is a plant-produced biomimetic peptide technology developed by LipoTrue.
“Biomimetic” means that an ingredient has been designed to imitate or support a process that occurs naturally within the body.
Reneseed™ is based on a biomimetic form of Transforming Growth Factor Beta-2, commonly shortened to TGFβ2. This is a signalling protein associated with processes involving the skin’s extracellular matrix and epidermal lipids.
In cosmetic skincare, Reneseed™ is used to support:
- Smoother-looking skin
- The appearance of firmness and elasticity
- Healthy-looking skin renewal
- Skin hydration and radiance
- The appearance of refined pores
- A stronger, more resilient-looking complexion
Reneseed™ is the supplier’s trade name. On the Re-Gen Peptide Power Serum ingredient list, it appears as:
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76
How Can a Plant Produce a Peptide?
This is where nature and biotechnology work together.
Reneseed™ is produced using Nicotiana benthamiana plants as biofactories. These plants are cultivated in a controlled vertical-farming environment and used to produce the specialised biomimetic peptide.
The process allows the plant to create a complex protein-based skincare ingredient.
Once produced, the peptide is collected and prepared for use in cosmetic formulations.
This does not mean the serum contains tobacco or behaves like a tobacco product. Nicotiana benthamiana is the plant used during the production process, which is why its botanical name forms part of the official INCI name.
The finished ingredient represents a sophisticated meeting point between plant-based production and modern peptide science.
Is Reneseed™ a Botanical Extract?
Not in the traditional sense.
A conventional botanical extract is usually produced by extracting naturally occurring compounds from plant material. Rooibos Extract and Malachite Extract, for example, are included in skincare for compounds already present in their original sources.
Reneseed™ is different.
The Nicotiana benthamiana plant acts as the production system for a specialised biomimetic peptide. The resulting ingredient is therefore better described as a plant-produced peptide technology rather than an ordinary plant extract.
This distinction is important because it explains why the INCI name appears much more complex than familiar botanical names.
How Does Reneseed™ Work in Skincare?
Reneseed™ was developed to support processes associated with the skin’s structure, renewal and protective function.
The skin’s extracellular matrix is a network of proteins and other components that provides structural support around skin cells. Collagen is one of the best-known proteins within this network.
The epidermis—the skin’s outer layer—also relies on lipids to help maintain its barrier and reduce excessive moisture loss.
As we age, the natural processes involved in maintaining these structures become less efficient. This can contribute to:
- Fine lines and wrinkles
- Reduced firmness
- Loss of elasticity
- More visible pores
- Dryness or dehydration
- A dull or tired-looking complexion
Reneseed™ is designed to support the pathways associated with extracellular matrix proteins and epidermal lipid production. In a cosmetic formulation, this can help skin look firmer, smoother, more hydrated and more resilient.
Is Reneseed™ a Retinoid?
No. Reneseed™ is not retinol, retinal or retinoic acid.
The supplier describes it as having retinol- and retinoic-acid-like activity in relation to the processes associated with collagen I production. This refers to similarities observed in the way the ingredient supports certain skin pathways.
It does not mean that Reneseed™ is chemically a retinoid or that it should be treated as one.
Unlike traditional retinoids, Reneseed™ was developed for use in both morning and evening skincare. It offers another option for people looking to support visible signs of ageing without necessarily introducing a conventional retinoid into their routine.
However, no cosmetic peptide should be presented as a direct replacement for a prescription treatment recommended by a medical professional.
Why Naturals Beauty Chose Reneseed™
When developing Re-Gen Peptide Power Serum, we wanted an advanced age-support formula that could be used consistently without depending on an aggressive exfoliating approach.
Reneseed™ was selected because it provides a sophisticated, plant-produced biomimetic peptide technology designed to support skin vitality and the appearance of firmness, elasticity and smoothness.
It complements Copper Tripeptide-1, Malachite Extract and hydrating humectants within the complete Re-Gen formula.
The purpose of combining these ingredients is not to produce an instant facelift or stop natural ageing. It is to provide targeted cosmetic support for skin showing fine lines, reduced firmness, loss of elasticity or a less resilient appearance.
Where You'll Find Reneseed™
Reneseed™ technology is a featured active in Naturals Beauty Re-Gen Peptide Power Serum.
Re-Gen is a lightweight, water-based and fragrance-free serum formulated for morning or evening use.
Its peptide-focused formula includes:
- Reneseed™ technology
- Copper Tripeptide-1
- Malachite Extract
- Glycerin
- Pentylene Glycol
Each ingredient has a different role. Reneseed™ and Copper Tripeptide-1 provide two distinct forms of peptide support. Malachite Extract contributes antioxidant care, while Glycerin and Pentylene Glycol help support hydration and a comfortable skin feel.
How Much Reneseed™ Is Used in Re-Gen?
Reneseed™ technology is used at 2% in Re-Gen Peptide Power Serum.
This percentage refers to the complete Reneseed™ technology as supplied and incorporated into the formulation.
It should not be described as "2% pure peptide".
Re-Gen also contains Copper Tripeptide-1 at 0.005%. These are separate ingredients used at their own formulation levels, and the percentages should not be added together to create a combined "peptide percentage".
Ingredient percentages cannot be compared only by looking at which number is higher. Cosmetic actives have different compositions, recommended use levels and functions within a finished formula.
What Is the INCI Name for Reneseed™?
Reneseed™ is the trade name of the ingredient technology.
In the complete Re-Gen ingredient list, it is declared as:
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76
Trade names help identify a supplier's specific cosmetic technology, while the INCI name is used in the ingredient declaration customers see on the product.
Ingredient Snapshot
Ingredient: Reneseed™ INCI declaration: Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 Ingredient type: Plant-produced biomimetic peptide technology Used in: Re-Gen Peptide Power Serum Use level in Re-Gen: 2% of the Reneseed™ technology Primary cosmetic role: Supports the appearance of skin vitality, firmness, elasticity and smoothness Suitable for: Adults looking for gentle, targeted age-support skincare Important clarification: Reneseed™ is not retinol, tobacco extract or 2% pure peptide
Reneseed™ Myths and Facts
Myth: Reneseed™ is tobacco extract Fact: The technology uses Nicotiana benthamiana as a plant biofactory in a controlled production process. It should not be described as applying tobacco extract to the skin.
Myth: Reneseed™ is a form of retinol Fact: Reneseed™ is a biomimetic peptide technology, not retinol. Supplier information describes retinoid-like activity in relation to Collagen I, but this does not make it a retinoid.
Myth: Re-Gen contains 2% pure peptide Fact: Re-Gen contains the complete Reneseed™ technology at 2%. This is different from claiming that the finished serum contains 2% pure peptide.
Myth: Reneseed™ and Copper Tripeptide-1 are the same ingredient Fact: They are two separate peptide ingredients with different identities and use levels in the Re-Gen formula.
Myth: A peptide serum can replace sunscreen Fact: Peptides can support the appearance and condition of the skin, but they do not protect it adequately from ultraviolet exposure. Broad-spectrum sunscreen remains an essential daytime step.
Did You Know?
Nicotiana benthamiana is frequently used in plant biotechnology because it can act as a biofactory for producing specific proteins and peptides.
In this context, the plant is part of the production platform — not the skincare benefit being claimed.
The resulting cosmetic technology is identified in the finished product through its INCI declaration, Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76.
Ask Our Formulator
Is Reneseed™ natural? Reneseed™ is best described accurately as a plant-produced biomimetic peptide technology. "Natural" can mean different things to different people, so explaining the production method is more useful than relying on a broad label.
Is Reneseed™ suitable for sensitive skin? Re-Gen is fragrance-free and was designed as a gentle age-support serum. However, every person's skin is different. Patch test a new product and introduce it gradually if your skin is sensitive.
Can Reneseed™ be used during the day? Yes. Re-Gen Peptide Power Serum can be used in the morning or evening. When it is used during the day, finish the routine with broad-spectrum sunscreen.
Can I use Re-Gen with vitamin C? For most people, vitamin C and peptide serums can form part of the same skincare routine. A simple approach is to use Glow Getter Vitamin C Serum in the morning and Re-Gen Peptide Power Serum in the evening.
Can I use Re-Gen with retinol? Peptides and retinol can be included in the same overall routine, although sensitive skin may benefit from using them at different times or on alternate evenings. Introduce active products gradually and follow professional guidance when using prescription treatments.
How long should I use Re-Gen before assessing it? Allow approximately four to eight weeks of consistent use. Supplier evaluation associated with the Reneseed™ technology included an assessment period of 28 days, but individual results can differ.
Continue Your Skincare Journey
Learn more about the ingredients and formula behind Re-Gen:
Inside the Ingredient #8 – Peptides Inside the Ingredient #9 – Copper Tripeptide-1 Inside the Ingredient #11 – Malachite Extract Behind the Formula #5 – Inside Our Re-Gen Peptide Power Serum How to Use a Peptide Serum in Your Skincare Routine Peptides vs Retinol: Which Is Right for Your Skin? What Age Should You Start Using a Peptide Serum? Can You Use Vitamin C and Peptide Serum Together?
Discover Nature, Backed by Science
Reneseed™ shows how plant biotechnology can be used to create a precise cosmetic ingredient for modern skincare.
Its inclusion in Re-Gen Peptide Power Serum supports our aim of combining botanical inspiration with carefully selected cosmetic science.
Reneseed™ does not promise to stop ageing or replace medical treatment. It forms part of a balanced formula designed to support smoother, firmer and healthier-looking skin through consistent care.